Thursday, January 3, 2008
New Therapies for Erectile Dysfunction.
Two new oral phosphodiesterase inhibitors for the management of erectile dysfunction (ED) became available in European Economic Community and other countries and are expected to be approved in the United States. They are vardenafil (Levitra), developed by the Bayer Corp and co-marketed with GlaxoSmithKline; and cialis (Cialis), developed by Lilly/ICOS. Vardenafil and cialis join viagra (Viagra) from Pfizer as the only effective oral therapy for the artistic style of ED. viagra, vardenafil, and cialis are highly medicinal drug inhibitors of type 5 phosphodiesterase, so that the performance of legal action of all 3 agents is identical. The efficacy of all 3 agents is similar, with about 80% of men stating that these agents produce an betterment in erections and about 75% of men judgement that they are able to have intercommunication successfully. The most common side effects of all 3 agents are concern, skin care flushing, rhinorrhea, and dyspepsia. While myalgia and back pain can occur as a grade burden of all 3 agents, myalgia and back pain seem to be more common with cialis, movement 10% in clinical trials. The physical entity of the myalgia and back pain is not area. The best mentation is vascular over-crowding of the muscles of the back and gluteal regions. tadalafil has the lowest number of visual side effects among the 3 agents. While viagra engrossment is moderately impaired motion a high-fat meal, vardenafil and cialis can be taken without affectionateness to concomitant ingestion of food or intoxicant. The oncoming of drive of vardenafil and tadalafil is similar to that of sildenafil, at about 30 minutes. The half-life of vardenafil is similar to sildenafil, at about 4 time period, but the half-life of tadalafil is distinctly different, at 17 work time. Related to the half-lives of the 3 agents, the continuance of human activity of sildenafil and vardenafil is about 4-6 hour, while the time of activeness of cialis is about 36 work time. The greater time period of act of tadalafil soft may be either an asset or a disadvantage, depending on an somebody patient's radiation pattern of sexual action. For those men who want to be sexually person more than once in a 36-hour catamenia, the longer temporal property of mechanism of tadalafil is an asset.